Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia
نویسندگان
چکیده
منابع مشابه
Genetic ablation of caveolin-1 confers protection against atherosclerosis.
OBJECTIVE The development of atherosclerosis is a process characterized by the accumulation of lipids in the form of modified lipoproteins in the subendothelial space. This initiating step is followed by the subsequent recruitment and proliferation of other cell types, including monocytes/macrophages and smooth muscle cells. Here, we evaluate the potential role of caveolae membrane domains in t...
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متن کاملGenetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells.
L-type, voltage-dependent calcium (Ca(2+)) channels, ryanodine-sensitive Ca(2+) release (RyR) channels, and large-conductance Ca(2+)-activated potassium (K(Ca)) channels comprise a functional unit that regulates smooth muscle contractility. Here, we investigated whether genetic ablation of caveolin-1 (cav-1), a caveolae protein, alters Ca(2+) spark to K(Ca) channel coupling and Ca(2+) spark reg...
متن کاملGenetic ablation of caveolin-1 modifies Ca spark coupling in murine arterial smooth muscle cells
Cheng, Xiaoyang, and Jonathan H. Jaggar. Genetic ablation of caveolin-1 modifies Ca spark coupling in murine arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 290: H2309–H2319, 2006. First published January 20, 2006; doi:10.1152/ajpheart.01226.2005.—Ltype, voltage-dependent calcium (Ca ) channels, ryanodine-sensitive Ca release (RyR) channels, and large-conductance Ca activated pota...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2020
ISSN: 1552-5783
DOI: 10.1167/iovs.61.11.32